It has been postulated that iNOS has a role in the pathogenesis of prostate cancer (Klotz et al. 1998), with iNOS expression levels proportional to Gleason grade, and indicators of proliferation (Ki-67, mitotic index and S-phase fraction) in prostate cancer patients (Aaltoma et al. 2001). Here, MKI67 is linked to Familial prostate cancer.