There is a significant body of evidence supporting the use of iNOS as a therapeutic transgene in cancer (Hatefi and Canine 2009; Tambe et al. 2017; Xu et al. 2017; Baltaci et al. 2001; Lee et al. 2009; Reschner et al. 2009; Gannon et al. 2010; Siemens et al. 2009; Holland et al. 2013). The gene discussed is NOS2; the disease is cancer.