IGHG1 and breast cancer: Intriguingly, expression level of a subset of the 60-gene B cell/plasma cell metagene is associated with worse prognosis in various cancer types that are reported (43, 67, 68), including the finding that expression of IGHG1 may be linked with tumor cell proliferation and immune evasion in pancreatic, lung, and breast cancer cell lines (69–72).