Previous studies have indicated that activation of the CaSR opens the Ca2+-activated K+ channel and non-selective cation channel in endothelial cells, neurons, and astrocytoma cells (Ye et al., 1996; Chattopadhyay et al., 1999a,b; Weston et al., 2005). Here, CASR is linked to astrocytoma (excluding glioblastoma).