MM cells are more often found adhered to stromal cells that secrete IL-6 and the secreted cytokine acts in a paracrine fashion and drives MM cells to proliferate at a faster pace by activating the prosurvival JAK/STAT signaling pathway (Kannaiyan et al., 2011, 2012; Sikka et al., 2014; Chai et al., 2015). This evidence concerns the gene SOAT1 and Miyoshi myopathy.