Constitutively active STAT3 is often encountered in several types of cancer cells including MM and plays a pivotal role in cancer cell survival and proliferation (Li F. et al., 2010; Kannaiyan et al., 2012; Subramaniam et al., 2013; Sikka et al., 2014; Chai et al., 2016; Shanmugam et al., 2016). Here, STAT3 is linked to cancer.