Several natural product compounds have been shown to inhibit the JAK/STAT signaling pathway in diverse cancer cells and preclinical models including MM cells (Li F. et al., 2010; Kannaiyan et al., 2011; Shanmugam et al., 2011; Yang et al., 2013; Lee et al., 2014; Siveen et al., 2014; Tang et al., 2014; Hsieh et al., 2015; Bishayee and Sethi, 2016; Baek et al., 2017a,b). This evidence concerns the gene SOAT1 and Miyoshi myopathy.