Interestingly, overexpression of SOCS abrogated IL-6 induced proliferation in MM cells, thereby suggesting another possible way to abrogate IL-6 induced downstream STAT3 signaling cascade (Bommert et al., 2006; Yamamoto et al., 2006; Kannaiyan et al., 2012; Kolosenko et al., 2014; Sikka et al., 2014). This evidence concerns the gene IL6 and Miyoshi myopathy.