Previous studies describing the cardioprotection provided by GATA-4-enriched BMSCs or exosomes have delivered them via intracardial injections before or at the very beginning of ischemia, that growth-promoting actions of GATA-4 is needed, Therefore, our protocol of injecting GATA-4 exosomes at 48 h after initiation of infarction was intended to highlight the actions of GATA-4 on the differentiation and proliferation of cardiomyocyte-like cells. Here, GATA4 is linked to ischemia.