ICOS and inborn error of immunity: In enrichment analyses, DE genes specific to lymphoid tissues were found to be involved in several immunity-related canonical pathways: “Th1 and Th2 Activation Pathway”, “Primary Immunodeficiency Signaling”, “Th1 Pathway”, “iCOS-iCOSL Signaling in T Helper Cells”, and “T Cell Receptor Signaling”.