ANGPTL4 and type 2 diabetes mellitus: We identified 21 additional variants that were predicted to inactivate one allele of ANGPTL4. Linking genetic variants to EHR-derived phenotypes, we found that p.E40K and other pLoF variants in ANGPTL4 were associated with reduced risk of type 2 diabetes, with p.E40K reaching genome-wide significance in analysis of 95,711 type 2 diabetes cases and 534,926 controls, and pLoFs reaching nominal significance in analyses of exome data from 32,015 type 2 diabetes cases and 84,006 controls.