We used a two-sided exact conditional test to combine the counts across studies given the low number of type 2 diabetes cases co-occurring with ANGPTL4 pLoFs, finding 29% lower odds of type 2 diabetes among carriers of pLoF variants (OR 0.71, 95% CI 0.49–0.99, p = 0.041). This evidence concerns the gene ANGPTL4 and type 2 diabetes mellitus.