In 15-week HF/HC-fed female mice BAT, Sort1 deficiency reduced mRNA levels of LXR-related genes (Nr1h3, Nr1h2, Abca1, Abcg1, Srebf1, Ppara), and sterol metabolism and trafficking genes (Hmgcr, Hmgcs1, Ch25h, Osbp2) (Fig. 5a and Supplementary Fig. S3b). This evidence concerns the gene PPARA and hydrops fetalis.