Sort1 deficiency reduced mRNA levels of LXRα/β (Nr1h3 and Nr1h2), LXR-related genes (Rxra, Cyp51, Srebf1, Sp1), sterol synthesis and metabolism genes (Hmgcr, Hmgcs1, Cyp27a1, Ch25h), and sterol trafficking genes (Lrp1, Vldlr, Osbp) in 15-week HF/HC-fed female mice WAT (Fig. 5a and Supplementary Fig. S3a). This evidence concerns the gene CH25H and hydrops fetalis.