Based on our results we present the following working model (Fig. 7): In HF/HC-fed female Ldlr−/− mice, Sort1 deficiency reduces LXR-mediated transcription, possibly in part via reduction of Klf4 mRNA levels in specific cell types, as exhibited by a lack of Klf4 mRNA levels change in intestinal tissue and cells. Here, SORT1 is linked to hydrops fetalis.