Due to the full-length isoform of SBSN potentially playing a more critical role in the development of AD (Text S4, Fig. 4c and S7) and IL-4 being involved in AD20, we examined the effects of IL-4 on human differentiating keratinocyte cultures and found decreased expression levels of SBSN in IL-4 treated compared to non-treated cultures (Fig. 4b). The gene discussed is IL4; the disease is Alzheimer disease.