Harazono et al. reported overexpression of miR-655 not only induced the up-regulation of E-cadherin and downregulation of typical EMT-inducers but also suppressed migration and invasion of mesenchymal-like cancer cells accompanied by a morphological shift toward the epithelial phenotype by targeting ZEB1 and TGFBR240. The gene discussed is CDH1; the disease is cancer.