An analysis of 206 specimens of bone tumours showed that among the indicators with diagnostic utility, including SP7, IHH, RUNX2, SOX9 and TWIST1, only RUNX2, TWIST1 and SOX9 are sensitive and specific factors that differentiate between chondroblastoma and chondromyxoid fibroma. This evidence concerns the gene SOX9 and chondroblastoma.