Accumulating evidence highlighted the importance of mitochondria in cancer cell metastasis.11, 12, 22, 32 Whether it was a mutation in NADH dehydrogenase subunit 6 (ND6),32 an overexpression of the survival protein survivin,12 or ETC overload and partial ETC inhibition,11 increased mtROS and associated redox deregulation was suggested as underlying mechanisms of metastasis promotion. The gene discussed is BIRC5; the disease is cancer.