To overcome this limitation, in the current study, we employed KM plotter (http://www.kmplot.com), a publicly available database portal with 5143 breast cancer cases including 1747 DMFS cases.18 Analyses of the KM plot data sets identified a significant association between high G1P3 expression and poor DMFS in breast cancer with a hazard ratio (HR) of 1.31, p ≤ 0.05 (Fig. 1a, left panel). This evidence concerns the gene IFI6 and breast cancer.