For example, ectopically expressed G1P3 lead to tamoxifen resistance in ER+ breast cancer cell line MCF-7, inhibited anoikis (detachment-induced apoptosis) to form hyperplasia in nontumourigenic mammary epithelial cell line MCF10A and silencing of G1P3 caused apoptosis of BT-549 cells as well as reduced the growth of MCF-7 cells.3 The gene discussed is IFI6; the disease is breast carcinoma.