BIRD-2 disrupts endogenous Bcl-2/IP3R complexes, thereby triggering Ca2+-driven apoptosis in different malignancies, including CLL [18, 20, 30], DLBCL [20], multiple myeloma [31], follicular lymphoma [31], and small cell lung cell carcinoma [32]. Here, ITPR3 is linked to B-cell chronic lymphocytic leukemia.