Via western-blot analysis, we measured the expression levels of IP3R2 and Bcl-2 in microsomes prepared from primary hepatocytes, which have a high IP3R2 density [26–28], in human liver carcinoma HepG2 cells and in the BIRD-2-sensitive (SU-DHL-4) and BIRD-2-resistant (OCI-LY-1) DLBCL cell lines (Fig. 1a). This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.