FADS1 and type 2 diabetes mellitus: Furthermore, a study evaluating the influence of FADS1 and FADS2 genetic variants on desaturase activity and lipid concentrations in 820 T2DM patients identified that FADS1 rs174547 and FADS2 rs2727270 genotypes were significantly correlated to lower levels of D5D and D6D activity in T2DM patients [34].