Thus, while available scoring systems for TACE such as the HAP score [21] are based on HCC-specific parameters like alpha-fetoprotein (AFP), pre-interventional measurements of IL-6 and IL-8 might be a valuable addition to future tumor-entity-independent stratification algorithms for TACE, which could further improve the clinical applicability of these scores. The gene discussed is IL6; the disease is hepatocellular carcinoma.