In this model, we demonstrated that intracellular ASAH1 was upregulated, and its secretion into extracellular space was also increased in the adult GBM cell line U87 and in the pediatric GBM cell line SJGBM2, suggesting that ASAH1 confers radioresistance to GBM (Figure 3) [96,97]. The gene discussed is ASAH1; the disease is glioblastoma.