More recently, circular RNAs (circRNAs) such as circSMARCA5, whose expression is downregulated in GBM samples as compared to control tissues, has been described to function as a novel tumor-suppressor, regulating the migration of GBM cells by modulating the oncoprotein that modulates cell migration, called RNA binding protein serine- and arginine-rich splicing factor 1 (SRSF1) [26]. This evidence concerns the gene SRSF1 and neoplasm.