Previous studies have demonstrated that p53 can be activated by lncRNA MEG3 [75]; lncRNA MEG3 is involved in proliferation and metastasis of gastric cancer by p53 [76]; lncRNA MEG3 inhibited NSCLC cells proliferation and promoted apoptosis by p53 [36]; lncRNA MEG3 can be interacted with p53 in hepatoma cells [77]. The gene discussed is TP53; the disease is hepatocellular carcinoma.