Subsequently, we assessed whether this reduction was sufficient to rescue the mis-splicing of BIN1 exon 11, which has been related to myopathy and T tubule alterations, and was also found to be among the genes with higher splicing disruption in DM1 (Thomas et al., 2017; Fugier et al., 2011). The gene discussed is BIN1; the disease is myotonic dystrophy type 1.