NFKB1 and neoplasm: Collectively, our data indicated that (i) HCC tumor-derived exosomes were actively incorporated into adipocytes and dramatically changed adipocytes transcripome and cytokine secretion; (ii) exo-adipocytes strongly supported tumor growth, enhanced angiogenesis, and recruited more macrophages; and (iii) several kinases and NF-κB signaling pathway were activated in exo-adipocytes (Fig. 8).