NDRG1 and squamous cell carcinoma: One study examining the effect of NDRG1 on lipid trafficking in the epidermoid carcinoma cell line A431 showed NDRG1 silencing-altered multivesicular body morphology, reduced low density lipoprotein uptake due to mislocalization of the LDL receptor, and decreased cholesterol ester levels, while increasing ceramide levels [7].