Similarly, the notion that the role of NDRG1 in the altered breast cancer metabolism associated with aggressive cells is in lipid management is supported by previous functional genomic studies [6, 8, 17] and that the lipid synthesis regulator Spot14 [42] is the most significantly downregulated gene in NDRG1 silenced SKBR3 cells. This evidence concerns the gene NDRG1 and breast carcinoma.