Lymphangiogenesis, which promotes tumor metastasis, is induced in the pre-metastatic niche by lymphangiogenic growth factors such as vascular endothelial growth factor (VEGF)-C, VEGF-D, angiopoietins, platelet-derived growth factor (PDGF)-BB/AA and basic fibroblast growth factor (bFGF) [2–6]. This evidence concerns the gene VEGFD and neoplasm.