CX3CL1 and Alzheimer disease: In the same direction, Mizuno et al. [78] showed that CX3CL1 reduced oxide nitric level in a dose-dependent manner, involved in neuroinflammation, whereas some authors found that the absence of expression of CX3CR1 in three different mouse AD models helped to protect against neuronal death by preventing microglial activation; they also found a lower amount of amyloid plaques [41, 79].