To address whether the PI3K/Akt/mTOR pathway was involved in KLF5-mediated regulation of hypoxia-induced DDP resistance in NSCLC cells, A549 cells were treated with Vector, pcDNA-KLF5 or combined with 10 μM LY294002 (a specific PI3K inhibitor) under hypoxia. Here, MTOR is linked to non-small cell lung carcinoma.