For example, treatment of dichloroacetate (DCA), an inhibitor of the glycolytic pathway, or genetic inhibition of pyruvate dehydrogenase kinase-1 (PDK-1), which is responsible for enhancing glycolysis, attenuated hypoxia-induced resistance to 5-fluorouracil (5-FU) in gastric cancer cells through the alteration of glucose metabolism [23]. The gene discussed is PDK1; the disease is gastric cancer.