CD274 and neoplasm: We were also able to describe a peculiar staining pattern for the PDL1-expressed RMS: a marked and continuous protein expression in both the immune cells infiltrating and surrounding the tumor (Fig. 1a and b) was observed in 10 RMS and a moderate, nest-like, focal and not diffuse pattern of PD-L1 protein expression exclusively in the immune cells surrounding the tumor burden (Fig. 1c and d) was reported in 4 RMS.