Global demethylation in KIT-mutated seminomas also may explain their significantly lower COSMIC mutational signature 1, because 5-methylcytosine, which occurs primarily in the CpG context, is 10 times more likely to mutate than a regular cytosine (C → T in the CpG context, explaining the majority of mutations that are observed in human cancers) (Shen and Laird, 2013). The gene discussed is KIT; the disease is seminoma.