RB1 and cancer: Given links between dysfunction of the retinoblastoma protein pRB, cohesion defects and chromosome lagging (Manning et al., 2010, Manning et al., 2014), and the propensity for chromosomes 1 and 2 to lag under conditions of mal-attachment and cohesion fatigue, it is possible that non-random mis-segregation could act in concert with evolutionary selection to drive these recurrent SCNA patterns in retinoblastomas and could potentially act more broadly across additional cancer types.