Finally, the accumulation of PDBs is also a feature of other neurological disorders with defective ATM, such as ataxia telangiectasia (A-T) and amyotrophic lateral sclerosis (ALS) (Alagoz et al., 2013, Katyal et al., 2014, Walker et al., 2017). The gene discussed is ATM; the disease is ataxia telangiectasia.