INS and Hyperglycemia: The β cell is tailored to deal with conditions of high glucose: the high-Km GLUT transporter (GLUT2), high-Km glucokinase, and high respiratory capacity in β cells result in a robust insulin secretory response to hyperglycemia (Heimberg et al., 1995, Heimberg et al., 1996, Díaz et al., 2007).