These data suggest that Becn1F121A-mediated autophagy hyperactivation may enhance insulin signaling through reducing ER stress in insulin-responsive cells, a key factor that causes insulin resistance (Flamment et al., 2012; Hummasti and Hotamisligil, 2010; Salvadó et al., 2015; Zhang et al., 2013). Here, INS is linked to Insulin resistance.