In addition, expression levels of certain miRNAs, such as miR-4649-5p andhsa-miR-4299, were significantly correlated with disease progression and mightbe useful as prognostic biomarkers (81).Another potential biomarker was mir-206, found to be upregulated in the plasmaof SOD1-G93A mice, an experimental ALS model, and in patients with confirmed ALS(82). Here, SOD1 is linked to amyotrophic lateral sclerosis.