In line with the observations from our previous studies, this study also showed that liraglutide could dose-dependently decrease cell viability and cell number, downregulate the protein level of the cell proliferation marker PCNA, and upregulate the protein levels of the pro-apoptotic markers Bax and cleaved caspase-3 in the human pancreatic cancer cell line MiaPaca-2. This evidence concerns the gene CASP3 and pancreatic neoplasm.