GLP1R and familial pancreatic carcinoma: To clarify whether GLP-1 receptor or AMPK signaling might also be involved in the synergistic anti-tumor effect of combined treatment with liraglutide and metformin on the pancreatic cancer cells, we determined the levels of GLP-1 receptor and p-AMPK using RT-PCR and/or western blot analyses in MiaPaca-2 cells treated with liraglutide or metformin alone or in combination.