STAT3 and obesity due to melanocortin 4 receptor deficiency: Additionally, as wet mass and type II mCSA increased in the SGI-1252 treated mice despite a similar rise in body mass, we speculate that inhibition of STAT3 may have reduced fat mass in the SGI-1252 treated mice, as studies have shown an association between STAT3 signaling, inflammation and obesity [47], yet we are unable to make this conclusion due to the lack of data.