In ADPKD, the ion secretory epithelium is defined by many changes in expression of ion channels including the cAMP activated cystic fibrosis transmembrane receptor (CFTR) chloride channel, the Na+-K+-2Cl- (NKCCl) co-transporter encoded by slc12a1 and -a2, and Ca2+ cation channels, among others[79–81]. The gene discussed is CFTR; the disease is autosomal dominant polycystic kidney disease.