SLC12A1 and autosomal dominant polycystic kidney disease: In ADPKD, the ion secretory epithelium is defined by many changes in expression of ion channels including the cAMP activated cystic fibrosis transmembrane receptor (CFTR) chloride channel, the Na+-K+-2Cl- (NKCCl) co-transporter encoded by slc12a1 and -a2, and Ca2+ cation channels, among others[79–81].