Interestingly, although cyst formation was not observed in single Fnip1fl/flCDH16-Cre or Fnip2fl/flCDH16-Cre kidneys, the authors did find increased kidney/body weight and small cyst formation in Fnip1fl/flFnip2fl/+CDH16-Cre kidneys (31). This evidence concerns the gene CDH16 and cyst.