MYC and renal carcinoma: Although Ingenuity was unable to predict activation versus repression for PGC1alpha or Myc in our RNAseq study (likely because the program does not take into account the presence or absence of co-activators, co-repressors, or dominating repressive complexes), increased Myc and PGC1alpha expression have been associated with PKD and renal cancer [17, 51, 52].