The median ACE2 level in patients with CAD was 29 pmol/ml/min which is higher than levels we previously reported in young healthy volunteers (4.44 ± 0.56 pmol/ml/min)[9] and in elderly patients (median 19.4 pmol/ml/min).[17] We excluded patients with known HF or severe LV systolic dysfunction as both are associated with increased circulating ACE2 levels.[11, 16] Consistent with results of other studies,[13–15, 22] plasma ACE2 activity was higher in male patients but we found no other independent predictors of plasma ACE2 activity levels. This evidence concerns the gene ACE2 and coronary artery disorder.