ACE2 and coronary artery disorder: Indeed, the location of the ACE2 gene within the X chromosome in an area where genes are known to escape X-inactivation may contribute to phenotypic differences between sexes and tissue-specific differences in X-inactivation.[31] Furthermore, the rs1978124 polymorphism in the ACE2 gene has been associated with poorer outcomes in two separate CAD cohorts of Chinese Han[32] and European[33] ancestry but there are not yet studies that combine genetic approaches with measurement of plasma ACE2 activity.[34]