VEGFA and stroke disorder: Figure 2A shows that APX3330 significantly increases arterial density (p<0.05, n=7/group) compared to PBS treated control T1DM stroke rats. However, total vascular density was significantly reduced in APX3330 treatment rats compared with PBS treated control T1DM stroke rats (p<0.05, n=7/group, Fig. 2B). APX3330 also significantly decreases VEGF expression in the IBZ (p<0.05, n=7/group, Fig. 2C) compared to PBS treated control T1DM stroke rats.