In comparison with samples from MCAO mice treated with normothermia, the expression level of iASPP significantly increased at 24 h (68.12 ± 10.98% in 33°C group versus 31.73 ± 6.31% in 37°C group, p = 0.001; Fig. 2A and B) and 72 h (93.25 ± 8.09% in 33°C group versus 44.86 ± 7.51% in 37°C group, p < 0.001; Fig. 2A and B;) after ischemia in the cortex and at 72 h after ischemia in the striatum under the application of mild therapeutic hypothermia (56.59 ± 6.46% in 33°C group versus 21.29 ± 3.78% in 37°C group, p = 0.002; Fig. 2A and B). Here, PPP1R13L is linked to ischemia.