We are currently in the process of assessing whether ACS can protect against cognitive decline in a model mouse produced by crossing human APOE4/E4 knock-in [44] mice with AD (App/Psen double-transgenic) model mice [45] to generate an App/Psen double-transgenic mouse with a human ApoE4/E4 knock-in. The gene discussed is APOE; the disease is Alzheimer disease.