APP and early-onset autosomal dominant Alzheimer disease: Also, eNOS-/- mice had increased amyloid precursor protein (APP), β-site APP-cleaving enzyme 1 (BACE1), and β-amyloid peptide (Aβ) in their brains compared to those of wild-type mice [37, 38], which contribute to the pathogenesis of Alzheimer’s disease (AD).