SDF-1/CXCR4/CXCR7 signaling axis is involved in many biological processes, including cardiovascular organogenesis, hematopoiesis, immune response, tumor growth and metastasis, as SDF-1 is a major factor of stem cell homing [1, 5-7], a process where the cells in the circulation migrate to the target tissues [8]. Here, CXCL12 is linked to neoplasm.