To investigate whether the effect of TOPK on microglia/macrophage polarization is mediated by the regulation of HDAC1/2, the expression of HDAC1, p-HDAC1, HDAC2, and p-HDAC2, and their co-localization with TOPK were examined in brain tissues subjected to cerebral ischemia-reperfusion. The gene discussed is HDAC1; the disease is brain ischemia.