Li et al. (2017) and Tang et al. (2017) have demonstrated that iron overload in mice induces the down-regulation of miR-122. Also, in patients with iron overload disorders, it was observed that miR-122 was decreased. Iron overload induces a significantly reduced expression of miR-122, which also increases HFE and HJV expression (Castoldi et al., 2011). The gene discussed is HJV; the disease is Tangier disease.