Studies in the murine model have showed that male rats consuming a high-fat diet predispose their female offspring to dysfunction of pancreatic β cells, accompanied by an increase in body weight, adiposity, glucose intolerance, and an alteration in insulin sensitivity (Carone et al., 2010; Ng et al., 2010; Ng S.F. et al., 2014). This evidence concerns the gene INS and Glucose intolerance.