We report the case of a 37-year-old man with a history starting at age 15 of recurrent episodes of angioedema of the head, trunk, and limbs, associated with myalgias, fever, hypereosinophilia [during an acute phase eosinophils had risen to 6,000/mm3 corresponding to 45% of circulating white cells and the eosinophil cationic protein (ECP) had risen to >200 μg/l], and also characterized by oliguria and weight gain (5–7 kg). This evidence concerns the gene RNASE3 and angioedema.