These results suggest that the IL-33/ST2 axis may also inhibit the production of TGF-β1 and reduce the infiltration of Tregs and MDSCs by inhibiting the expression of chemokines such as CCL20 and CXCL5 in the tumor microenvironment of STS, thus contribute to antagonizing Tregs, MDSCs, and TGF-β1-mediated immunosuppression. The gene discussed is CXCL5; the disease is telomere syndrome.