CD8A and neoplasm: Recently, evidence has also shown that IL-33 can play an antitumor role by promoting the immune response of natural killer cells (NKs) and CD8+ T cells and enhancing IFN-γ production (15–17), which suggests that IL-33 is a potent cytokine for reversing the immunosuppressive tumor microenvironment and promoting antitumor immunity (16, 18).