However, we found that IL-33 was negatively correlated with the expression of the chemokines CCL20 and CXCL5, as well as with TGF-β1, in STS, suggesting that the IL-33/ST2 axis may reverse immunosuppression mainly by reducing the infiltration of Tregs and MDSCs and inhibiting the production of TGF-β1 in the STS tumor microenvironment. The gene discussed is IL1RL1; the disease is telomere syndrome.