By analyzing sarcoma data of TCGA and GEO, we found that the transcriptional levels of IL-33 and ST2 were positively correlated with those of CD3E, CD8A, IFN-γ, and chemokines that recruit CD8+ T cells, indicating that the IL-33/ST2 axis may play an important role in promoting the recruitment of CD8+ T cells and enhancing IFN-γ production in STS. This evidence concerns the gene IL1RL1 and sarcoma.