These results suggest that the IL-33/ST2 axis may also inhibit the production of TGF-β1 and reduce the infiltration of Tregs and MDSCs by inhibiting the expression of chemokines such as CCL20 and CXCL5 in the tumor microenvironment of STS, thus contribute to antagonizing Tregs, MDSCs, and TGF-β1-mediated immunosuppression. This evidence concerns the gene IL33 and neoplasm.