The utilization of a mouse model of food allergy to understand the biological role of IL-12Rβ2 in controlling the production of IEC-derived cytokines led to the parallel finding that the suppression of food allergy by IL-12 was indirectly linked to the downregulation of TSLP but did not affect levels of another allergy-critical epithelium-derived cytokine, IL-33. This evidence concerns the gene IL12RB2 and food allergy.