Interestingly, when cTfh1, cTfh17, and cTfh2 CD4+CD45RA−CXCR5+ subpopulations were evaluated, we found a lower percentage of cTfh2 cells in untreated RRMS patients compared to controls (37.4 vs. 49.9%; p < 0.001) (Figure 2K), whereas the percentage of cTfh17.1 was significantly increased (10.0 vs. 4.2%; p < 0.001) (Figure 2L). The gene discussed is CD4; the disease is relapsing-remitting multiple sclerosis.