CD4 and relapsing-remitting multiple sclerosis: We further studied the distribution of different subsets of circulating effector T helper non-follicular (Th) CD4+CD45RA−CXCR5− and follicular (cTfh) CD4+CD45RA−CXCR5+ cells, identified according to the expression of CXCR3 and CCR6 markers in untreated RRMS patients and controls: Th1/cTfh1 (CXCR3+CCR6−), Th2/cTfh2 (CXCR3−CCR6−), Th17/cTfh17 (CXCR3−CCR6+), and Th17.1/cTfh17.1 (CXCR3+CCR6+) (Figure 2D).