PGP and lymphoma: For example, the inhibition of an MDR efflux pump (P-glycoprotein – P-gp) by chalcones was previously assessed through testing distinct methoxy-chalcones B-ring derivatives in a human mdr1 gene transfected into a mouse lymphoma cell line, which showed a high binding affinity to P-gp, exceeding that of a known MDR blocking agent (Ivanova et al., 2008).