VEGFA and hyperprolactinemia: The rationale underlying this treatment is based on the fact that levosulpiride effectively induces hyperprolactinemia, and preclinical studies show that hyperprolactinemia leads to the accumulation of intraocular vasoinhibins able to counteract diabetes-induced retinal vascular alterations by blocking not only the effects of VEGF (17, 18), but of other contributing factors in the vitreous of RD and DME patients (20, 29).