↑51Cr-EDTA in patients versus controls at T1 and no difference at T2. ↓Intestinal permeability in patients during the treatment. ↑Plasma LPS in patients versus controls at T1, significantly ↓ during withdrawal and no difference from controls at T2. A low-grade inflammation observed at T1 and partially ↓ during withdrawal. At T1 pro-inflammatory cytokines significantly correlated with craving. At T2 anti-inflammatory IL-10 negatively correlated with depression, anxiety and craving. This evidence concerns the gene IL10 and major depressive disorder.