Using a rat model of surgically induced IUGR and in utero exposure to maternal HFD consumption, we hypothesized that weanling IUGR rats exposed to a maternal HFD in utero would have increased cholesterol, decreased Cyp7a1 protein, increased hepatic bile acids, and increased miR-122 compared to non-IUGR rats exposed to the same maternal HFD. The gene discussed is CYP7A1; the disease is fetal growth restriction.