In cerulein-induced acute pancreatitis, fluid hypersecretion was observed in rats (Czakó et al., 1997); furthermore, genetic deletion of Cftr (Dimagno et al., 2005) as well as deletion of its trafficking regulator Na+/H+ exchanger regulatory factor-1 (Nherf-1) (Pallagi et al., 2014) resulted in a more severe acute pancreatitis phenotype in mice. Here, CFTR is linked to acute pancreatitis.